Amaha / / / Are Some People More Prone to Depression?
ARTICLE | 5 MIN MINS READ
Are Some People More Prone to Depression?
Published on
30th Oct 2025
Dr Janani Vasanth
MD Psychiatry
Depression is a mental illness that affects millions of people worldwide. It is characterised by feelings of sadness, hopelessness, and a loss of interest in activities that one used to enjoy. According to the World Health Organisation, more than 264 million people worldwide suffer from depression. While anyone can experience depression, some people may be more prone to the condition than others. In this article, we will explore the factors that can make someone more susceptible to depression.
Also read: Sadness vs. Depression: How to Tell the Difference
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Genetics
Research shows that genetics can influence the likelihood of developing depression. Individuals with a family history of depression are at a higher risk of experiencing it themselves. According to the American Psychiatric Association, people with a first-degree relative (such as a parent or sibling) who has depression are two to three times more likely to develop it. While genes alone don’t determine one’s mental health, they can interact with environmental and psychological factors, increasing vulnerability. Understanding genetic links helps clinicians identify at-risk individuals and offer early intervention strategies for prevention and support.
Brain chemistry
Brain chemistry plays a key role in the onset of depression. Imbalances in neurotransmitters such as serotonin, dopamine, and norepinephrine, chemicals that regulate mood and emotions, can disrupt how the brain processes pleasure, motivation, and stress.
These irregularities may increase an individual's susceptibility to persistent sadness or fatigue. Additionally, changes in brain structure and function, particularly in areas like the hippocampus and prefrontal cortex, are often associated with depression. Addressing these chemical and structural factors through therapy or medication can help restore balance and improve emotional well-being.
Life events
Traumatic or stressful life events, such as the loss of a loved one, a divorce, or a major illness, can trigger depression in some individuals. Research indicates that people who face a major life stressor within the past year are more likely to develop depression. However, the impact varies from person to person; support systems, coping skills, and resilience can all influence how one responds to life’s challenges and emotional setbacks.
Personality traits
Certain personality traits can make individuals more prone to depression. People with low self-esteem, a pessimistic outlook, or a strong tendency toward self-criticism often find it harder to cope with stress and negative experiences. Perfectionists or those who set unrealistically high standards for themselves may also experience feelings of inadequacy or failure, heightening their risk. Similarly, individuals who are overly dependent on external validation or have difficulty expressing emotions may struggle to manage internal distress effectively. Recognising these traits can help guide therapeutic approaches and build emotional resilience.
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Other health conditions
Depression often coexists with other health conditions that can either trigger or worsen symptoms. Chronic illnesses such as diabetes, heart disease, or arthritis may lead to persistent pain, fatigue, and emotional strain, increasing vulnerability to depression. Hormonal fluctuations during pregnancy, postpartum periods, or menopause can also affect mood regulation.
Substance use disorders, including alcohol or drug dependence, further complicate mental health by altering brain chemistry and lifestyle stability. Managing these conditions holistically, through medical care, therapy, and lifestyle support, can significantly reduce the impact of depression and improve overall well-being.
Treatment
While depression can be a debilitating condition, it is also highly treatable. Treatment options may include therapy, medication, or a combination of both. In addition, lifestyle changes such as regular exercise, a healthy diet, and stress-reducing activities can also help manage symptoms of depression.
Conclusion
Depression can affect anyone, but some people may be more prone to the condition than others. If you or a loved one is struggling with depression, know that there is help available. Seek out a mental health professional who can help you manage your symptoms and develop a recovery plan.
